abstract：:Trained people exhibit low plasma concentrations of triacylglcyeride (TAG) in both fasted and postprandial states. This mainly reflects enhanced uptake of TAG into skeletal muscle, via enhanced activity of lipoprotein lipase, the rate-limiting step in TAG removal. Endurance athletes possess a large, well-vascularised ...

journal_title：Atherosclerosis

authors： Hardman AE

更新日期：1998-12-01 00:00:00

abstract：:To determine whether high prevalence of small dense low-density lipoprotein (LDL) in non-insulin-dependent diabetes (NIDDM) with nephropathy is directly associated with kidney damage, we measured LDL particle size by non-denaturing 2-16% gradient polyacrylamide gel electrophoresis in non-diabetic patients with primary...

journal_title：Atherosclerosis

authors： Hirano T,Oi K,Sakai S,Kashiwazaki K,Adachi M,Yoshino G

更新日期：1998-11-01 00:00:00

abstract：:The Del allele of the apolipoprotein B (apoB) signal peptide (SP) insertion/deletion (Ins/Del) polymorphism has been shown to be associated with elevated plasma levels of apoB, cholesterol and low density lipoprotein. It was the aim of the present study to analyse the relation of this gene variation to the risk of cor...

journal_title：Atherosclerosis

authors： Gardemann A,Ohly D,Fink M,Katz N,Tillmanns H,Hehrlein FW,Haberbosch W

更新日期：1998-11-01 00:00:00

abstract：:Animal models are used extensively in the ongoing investigation of a possible causal link between Chlamydia pneumoniae infection and conditions such as asthma and cardiovascular disease. Respiratory infections have been studied in monkeys, while mouse and rabbit models have been used to study both respiratory and card...

journal_title：Atherosclerosis

authors： Saikku P,Laitinen K,Leinonen M

更新日期：1998-10-01 00:00:00

abstract：:Atherosclerotic plaque rupture and erosions precipitate thrombus formation and may lead to an acute ischemic syndrome. Lipids and lipoproteins modulate the expression and/or function of thrombotic, fibrinolytic and rheologic factors, and thereby influence hemostasis and potential tissue damage resulting from vascular ...

journal_title：Atherosclerosis

authors： Rosenson RS,Lowe GD

更新日期：1998-10-01 00:00:00

abstract：:The present study focused on the role of blood flow in the formation of focal intimal hyperplasia in vein grafts, as well as the development of an engineering approach that can be used to eliminate disturbed blood flow and prevent blood flow-related focal intimal hyperplasia. A rat vein graft model was constructed by ...

journal_title：Atherosclerosis

authors： Liu SQ

更新日期：1998-10-01 00:00:00

abstract：:Long-term dietary omega-3 fatty acids improve coronary endothelial function in CAD patients, heart transplant recipients and diabetics. This study assessed whether short term omega-3 fatty acids affect radial artery function in CAD patients. A high resolution A-mode echotracking device (NIUS 02) was used to measure co...

journal_title：Atherosclerosis

authors： Kothny W,Angerer P,Störk S,von Schacky C

更新日期：1998-09-01 00:00:00

abstract：:Extensive research has been carried out in recent years to discover the potential risk factors contributing to cardiac allograft atherogenesis. Injury to endothelial cells has been regarded as an important early mechanism in the development of transplant atherosclerosis; it leads to the manifestation of epicardial and...

journal_title：Atherosclerosis

authors： Liu Z,Wildhirt SM,Weismüller S,Schulze C,Conrad N,Reichart B

更新日期：1998-09-01 00:00:00

abstract：:To investigate the growth-regulating action of estrogen on vascular smooth muscle cells (SMC), effects of beta-17-estradiol (beta-E2) on phenotypic modulation and proliferation of rabbit aortic SMC were observed in vitro. At 10(-8)M, beta-E2 significantly slowed the decrease in volume fraction of myofilaments (Vv myo)...

journal_title：Atherosclerosis

authors： Song J,Wan Y,Rolfe BE,Campbell JH,Campbell GR

更新日期：1998-09-01 00:00:00

abstract：:Occlusive arterial disease stimulates compensatory growth of pre-existent and new arterial channels which help to maintain organ perfusion. Previous studies characterizing compensatory or collateral vascular growth have been performed in normocholesterolemic animals. Because hyperlipidemic states alter vascular regula...

journal_title：Atherosclerosis

authors： Bucay M,Nguy J,Barrios R,Chen CH,Henry PD

更新日期：1998-08-01 00:00:00

abstract：:Inducible nitric oxide synthase (iNOS) has recently been shown to be present in human atherosclerotic lesions and to promote the formation of deleterious peroxynitrite. Allicin and ajoene are discussed as active compounds with regard to the beneficial effects of garlic in atherosclerosis. The aim of this study was to ...

journal_title：Atherosclerosis

authors： Dirsch VM,Kiemer AK,Wagner H,Vollmar AM

更新日期：1998-08-01 00:00:00

abstract：:Local accumulation of cells (hypercellularity) in the intima of the arterial wall as a result of cell proliferation is recognized as one of the major manifestations of human atherosclerosis. In the present study we have used a monoclonal antibody against PCNA to identify the proliferative activity, in uninvolved intim...

journal_title：Atherosclerosis

authors： Orekhov AN,Andreeva ER,Mikhailova IA,Gordon D

更新日期：1998-07-01 00:00:00

abstract：:In a sample taken from the genetically isolated Alberta Hutterites, we previously found that PON1 variation was associated with variation in plasma lipoprotein traits, including LDL and HDL cholesterol. With the recent cloning of the PON1-related gene PON2, we undertook studies of the association between genetic varia...

journal_title：Atherosclerosis

authors： Boright AP,Connelly PW,Brunt JH,Scherer SW,Tsui LC,Hegele RA

更新日期：1998-07-01 00:00:00

abstract：:Increased atherosclerosis risk in hyperlipidemic patients may be a result of the enhanced oxidizability of their plasma lipoproteins. We have previously shown that hypocholesterolemic drug therapy, including the 3-hydroxy-3-methyl-glutaryl CoenzymeA (HMG-CoA) reductase inhibitors, and the hypotriglyceridemic drug beza...

journal_title：Atherosclerosis

authors： Aviram M,Rosenblat M,Bisgaier CL,Newton RS

更新日期：1998-06-01 00:00:00

abstract：:Paraoxonase (PON) is an HDL-bound enzyme capable of hydrolyzing lipid peroxides and believed to be in part responsible for the protective effect of HDL against LDL oxidation. Its activity is mainly determined by a gene polymorphism of the PON 1 gene (Glu-Arg 192). Low activity has been related to an elevated incidence...

journal_title：Atherosclerosis

authors： Cao H,Girard-Globa A,Serusclat A,Bernard S,Bondon P,Picard S,Berthezene F,Moulin P

更新日期：1998-06-01 00:00:00

abstract：:This study examined the effects of lovastatin supplementation (25 mg/kg per day) in conjunction with an atherogenic diet (10% coconut oil (w/w), 0.05% cholesterol) on regression of pre-existing foam cells and on hepatic and intestinal LDL receptor and HMG CoA reductase mRNA levels. F1B hamsters fed the atherogenic die...

journal_title：Atherosclerosis

authors： Pitman WA,Osgood DP,Smith D,Schaefer EJ,Ordovas JM

更新日期：1998-05-01 00:00:00

abstract：:The role of the immune system in modulating atherosclerosis has recently been the subject of intensive research. Several previous authors have put forward a paradigm of the autoimmune process occurring in the vicinity of the plaque. Two recent studies have shown that immunization of rabbits with homologous modified lo...

journal_title：Atherosclerosis

authors： George J,Afek A,Gilburd B,Levkovitz H,Shaish A,Goldberg I,Kopolovic Y,Wick G,Shoenfeld Y,Harats D

更新日期：1998-05-01 00:00:00

abstract：:Tranilast (N(3,4-dimethoxycinnamoyl)anthranilic acid), an agent which in cell culture inhibits transforming growth factor-beta (TGF-beta) secretion and antagonises the effects of TGF-beta and platelet-derived growth factor (PDGF) on cell migration and proliferation, has been reported to reduce the incidence of resteno...

journal_title：Atherosclerosis

authors： Ward MR,Sasahara T,Agrotis A,Dilley RJ,Jennings GL,Bobik A

更新日期：1998-04-01 00:00:00

abstract：:Previous studies have shown that the A to G transition occurring at position -75 bp upstream of the transcriptional start site in the human apolipoprotein A-I gene may affect plasma high density lipoprotein cholesterol (HDL-C) levels and low density lipoprotein cholesterol (LDL-C) response to changes in amount of diet...

journal_title：Atherosclerosis

authors： Mata P,Lopez-Miranda J,Pocovi M,Alonso R,Lahoz C,Marin C,Garces C,Cenarro A,Perez-Jimenez F,de Oya M,Ordovas JM

更新日期：1998-04-01 00:00:00

abstract：:There exists much evidence suggesting a major role for the oxidized low density lipoprotein (LDL) and VLDL particles in the pathogenesis of atherosclerosis. Although obesity is characterized by dyslipidemia, less is known about the oxidation capacity of lipoproteins in obese subjects. We measured the oxidizability in ...

journal_title：Atherosclerosis

authors： Van Gaal LF,Vertommen J,De Leeuw IH

更新日期：1998-04-01 00:00:00

abstract：:Methodological differences and variations in health care regulations among countries often preclude direct comparisons of cost-effectiveness studies. A projected risk model was applied, designed to determine the economic value in the United States of pravastatin in the secondary prevention of coronary heart disease (C...

journal_title：Atherosclerosis

authors： Muls E,Van Ganse E,Closon MC

更新日期：1998-04-01 00:00:00

abstract：:Oxidation of low density lipoproteins (LDL) is considered a key event in the pathogenesis of atherosclerotic lesions. Disturbed generation of coagulatory and anticoagulatory factors by endothelial cells contributes to thrombosis and the progression of atherosclerosis in coronary arteries. In this study, the effects of...

journal_title：Atherosclerosis

authors： Gräfe M,Auch-Schwelk W,Hertel H,Terbeek D,Steinheider G,Loebe M,Fleck E

更新日期：1998-03-01 00:00:00

abstract：:Consecutive patients (n=964) undergoing coronary angiography were studied and compared with a random population sample regarding serum lipids and lipoproteins with focus on lipoprotein(a) (Lp[a]) levels and apo(a) isoforms. The patients were also followed for 5 years after the angiography, and the prognostic value of ...

journal_title：Atherosclerosis

authors： Lindén T,Taddei-Peters W,Wilhelmsen L,Herlitz J,Karlsson T,Ullström C,Wiklund O

更新日期：1998-03-01 00:00:00

abstract：:Oxidant signalling and lipoprotein oxidation may play important roles in atherosclerotic lesion development. Given coincident localization of 15-lipoxygenase (15-LO), stereospecific products of 15-LO and epitopes of modified LDL in atherosclerotic lesions, we hypothesized that inhibition of 15-LO by PD146176, an inhib...

journal_title：Atherosclerosis

authors： Bocan TM,Rosebury WS,Mueller SB,Kuchera S,Welch K,Daugherty A,Cornicelli JA

更新日期：1998-02-01 00:00:00

abstract：:Familial hypobetalipoproteinemia is an autosomal co-dominant disorder, which in a minority of cases is due to a truncation producing mutation in the apoB gene. We have identified an apoB mutation in a 40-year old hypobetalipoproteinemic man with Type II diabetes mellitus. Immunoblotting of plasma revealed a major band...

journal_title：Atherosclerosis

authors： Pulai JI,Latour MA,Kwok PY,Schonfeld G

更新日期：1998-02-01 00:00:00

abstract：:This study sought to examine the association between cigarette smoking and serum bilirubin antioxidant concentrations in 715 middle-aged men undergoing coronary angiography. The study involved 153 current smokers, 251 who quit smoking and 311 who never smoked. Serum bilirubin concentrations were divided into the follo...

journal_title：Atherosclerosis

authors： Schwertner HA

更新日期：1998-02-01 00:00:00

abstract：:Previous work has shown that oxidized low density lipoprotein (Ox-LDL) inhibited lipopolysacchride (LPS)-induced nitric oxide (NO) production in macrophages. In this paper, the role of different components of Ox-LDL in the inhibitory effect was studied by measuring nitrite in media. Ox-LDL inhibited LPS-induced NO pro...

journal_title：Atherosclerosis

authors： Liu SX,Chen Y,Zhou M,Wan J

更新日期：1998-01-01 00:00:00

abstract：:In general, plasma concentrations of high density lipoproteins (HDL) are inversely related to the incidence of coronary artery disease. One exception to this trend is individuals with apolipoprotein A-I(Milano) (apo A-IM), a molecular variant of apo A-I, which results in very low plasma apo A-I and HDL-cholesterol lev...

journal_title：Atherosclerosis

authors： Chiesa G,Stoltzfus LJ,Michelagnoli S,Bielicki JK,Santi M,Forte TM,Sirtori CR,Franceschini G,Rubin EM

更新日期：1998-01-01 00:00:00

abstract：:Fractional esterification rate of cholesterol in high density lipoprotein (HDL) (FER[HDL]) can predict the size distribution and physicochemical characteristics of HDL in plasma. In the present study, we investigated the correlation of FER(HDL) with the particle size of low density lipoprotein (LDL) (LDL-size) in 111 ...

journal_title：Atherosclerosis

authors： Ohta T,Saku K,Takata K,Nagata N,Maung KK,Matsuda I

更新日期：1997-12-01 00:00:00

abstract：:Human aortic aneurysm is commonly characterized by the presence of advanced atherosclerosis associated with variable chronic adventitial inflammation. Histological examination of human aortic aneurysmal specimens revealed the presence of plasma cells and lymphoid aggregates in media and adventitia of the vessels. Immu...

journal_title：Atherosclerosis

authors： Yen HC,Lee FY,Chau LY

更新日期：1997-11-01 00:00:00

abstract：:The pyridine derivative cerivastatin is a new entirely synthetic and enantiomerically pure inhibitor of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. As a sodium salt cerivastatin is present in the active, open ring form. Cerivastatin inhibited the membrane-bound (non-solubilized) HMG-CoA reductase of the native...

journal_title：Atherosclerosis

authors： Bischoff H,Angerbauer R,Bender J,Bischoff E,Faggiotto A,Petzinna D,Pfitzner J,Porter MC,Schmidt D,Thomas G

更新日期：1997-11-01 00:00:00

abstract：:SR-12813 inhibits cholesterol biosynthesis in Hep G2 cells via an enhanced degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. Here we also show that SR-12813 inhibits cholesterol biosynthesis in vivo. A sterol balance study was performed in normolipemic beagle dogs. The dogs were given SR-12813 ...

journal_title：Atherosclerosis

authors： Berkhout TA,Simon HM,Jackson B,Yates J,Pearce N,Groot PH,Bentzen C,Niesor E,Kerns WD,Suckling KE

更新日期：1997-09-01 00:00:00

abstract：:Numerous epidemiological studies have shown that lipoprotein(a) (Lp(a)) is an independent risk factor for the premature development of cardiovascular disease. In spite of such evidence, the structural and functional features of this atherogenic, cholesterol-rich particle are not clearly understood. We have demonstrate...

journal_title：Atherosclerosis

authors： Huby T,Chapman J,Thillet J

更新日期：1997-08-01 00:00:00

abstract：:Endothelium-derived relaxing and contracting factors play an important role in atherosclerosis, re-stenosis and graft survival. Internal thoracic artery (ITA) and saphenous vein (SV) are used as conduit vessels in coronary artery bypass graft surgery (CABG). The long-term graft patency rate is higher with ITA than SV....

journal_title：Atherosclerosis

authors： Hamilton CA,Berg G,Mcintyre M,Mcphaden AR,Reid JL,Dominiczak AF

更新日期：1997-08-01 00:00:00

abstract：:Two specific endothelial cell products, von Willebrand factor and soluble E-selectin, were measured together with serum lipids, lipoprotein(a), systolic and diastolic blood pressure (SHP, DBP) in a follow up study of 162 patients attending a dedicated lipid clinic. Patients were further classified by the presence or a...

journal_title：Atherosclerosis

authors： Blann AD,Miller JP,McCollum CN

更新日期：1997-07-25 00:00:00

abstract：:Leptin is the peptide product of the OB gene, which is associated with obesity in some strains of mice. Because dyslipidemias are frequently associated with obesity, we have begun to characterize the pathways connecting these related traits. In this investigation we tested for correlation of HDL phenotype measures wit...

journal_title：Atherosclerosis

authors： Rainwater DL,Comuzzie AG,VandeBerg JL,Mahaney MC,Blangero J

更新日期：1997-07-25 00:00:00

abstract：:Vitamin K is involved in the biosynthesis of a number of blood coagulation factors and bone proteins. It has been suggested that the vitamin K requirement of bone tissue is higher than that of the liver. Here we report that in rats very high doses of vitamin K affected neither the blood coagulation characteristics nor...

journal_title：Atherosclerosis

authors： Ronden JE,Groenen-van Dooren MM,Hornstra G,Vermeer C

更新日期：1997-07-11 00:00:00

abstract：:The possibility that Fas/APO 1 is involved in the apoptosis of advanced human coronary atherosclerosis was examined in the present study. Coronary arteries with atherosclerosis were obtained from human hearts with chronic ischemic heart disease at cardiac transplantation. Normal vessels were used as controls. Fas/APO ...

journal_title：Atherosclerosis

authors： Cai W,Devaux B,Schaper W,Schaper J

更新日期：1997-06-01 00:00:00

abstract：:Apolipoprotein E (apo E) is a component of all the classes of lipoproteins and can be distributed among apo B- (LpB) and non apo B-containing lipoproteins (Lp-non-B). Using a new electroimmunoassay kit, plasma apo E, apo E in Lp-non-B (apo E-Lp-non-B) and apo E in LpB (apo E-LpB) levels were measured in healthy contro...

journal_title：Atherosclerosis

authors： Luc G,Ducimetiere P,Bard JM,Arveiler D,Evans A,Cambien F,Fruchart JC,Fievet C

更新日期：1997-06-01 00:00:00

abstract：:Preclinical and clinical data on atorvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, indicate that it has superior activity in treating a variety of dyslipidemic disorders characterized by elevations in low-density lipoprotein cholesterol (LDL-C) and/or triglycerides. Results for p...

journal_title：Atherosclerosis

authors： Bakker-Arkema RG,Best J,Fayyad R,Heinonen TM,Marais AD,Nawrocki JW,Black DM

更新日期：1997-05-01 00:00:00